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Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.

Identifieur interne : 000341 ( Main/Exploration ); précédent : 000340; suivant : 000342

Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.

Auteurs : Li Qi [États-Unis] ; A Sally Davis ; Brett W. Jagger ; Louis M. Schwartzman ; Eleca J. Dunham ; John C. Kash ; Jeffery K. Taubenberger

Source :

RBID : pubmed:22718825

Descripteurs français

English descriptors

Abstract

The 1918-1919 "Spanish" influenza pandemic is estimated to have caused 50 million deaths worldwide. Understanding the origin, virulence, and pathogenic properties of past pandemic influenza viruses, including the 1918 virus, is crucial for current public health preparedness and future pandemic planning. The origin of the 1918 pandemic virus has not been resolved, but its coding sequences are very like those of avian influenza virus. The proteins encoded by the 1918 virus differ from typical low-pathogenicity avian influenza viruses at only a small number of amino acids in each open reading frame. In this study, a series of chimeric 1918 influenza viruses were created in which each of the eight 1918 pandemic virus gene segments was replaced individually with the corresponding gene segment of a prototypical low-pathogenicity avian influenza (LPAI) H1N1 virus in order to investigate functional compatibility of the 1918 virus genome with gene segments from an LPAI virus and to identify gene segments and mutations important for mammalian adaptation. This set of eight "7:1" chimeric viruses was compared to the parental 1918 and LPAI H1N1 viruses in intranasally infected mice. Seven of the 1918 LPAI 7:1 chimeric viruses replicated and caused disease equivalent to the fully reconstructed 1918 virus. Only the chimeric 1918 virus containing the avian influenza PB2 gene segment was attenuated in mice. This attenuation could be corrected by the single E627K amino acid change, further confirming the importance of this change in mammalian adaptation and mouse pathogenicity. While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus.

DOI: 10.1128/JVI.00887-12
PubMed: 22718825
PubMed Central: PMC3416129


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<term>Virus de la grippe A (métabolisme)</term>
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<div type="abstract" xml:lang="en">The 1918-1919 "Spanish" influenza pandemic is estimated to have caused 50 million deaths worldwide. Understanding the origin, virulence, and pathogenic properties of past pandemic influenza viruses, including the 1918 virus, is crucial for current public health preparedness and future pandemic planning. The origin of the 1918 pandemic virus has not been resolved, but its coding sequences are very like those of avian influenza virus. The proteins encoded by the 1918 virus differ from typical low-pathogenicity avian influenza viruses at only a small number of amino acids in each open reading frame. In this study, a series of chimeric 1918 influenza viruses were created in which each of the eight 1918 pandemic virus gene segments was replaced individually with the corresponding gene segment of a prototypical low-pathogenicity avian influenza (LPAI) H1N1 virus in order to investigate functional compatibility of the 1918 virus genome with gene segments from an LPAI virus and to identify gene segments and mutations important for mammalian adaptation. This set of eight "7:1" chimeric viruses was compared to the parental 1918 and LPAI H1N1 viruses in intranasally infected mice. Seven of the 1918 LPAI 7:1 chimeric viruses replicated and caused disease equivalent to the fully reconstructed 1918 virus. Only the chimeric 1918 virus containing the avian influenza PB2 gene segment was attenuated in mice. This attenuation could be corrected by the single E627K amino acid change, further confirming the importance of this change in mammalian adaptation and mouse pathogenicity. While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus.</div>
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<AbstractText>The 1918-1919 "Spanish" influenza pandemic is estimated to have caused 50 million deaths worldwide. Understanding the origin, virulence, and pathogenic properties of past pandemic influenza viruses, including the 1918 virus, is crucial for current public health preparedness and future pandemic planning. The origin of the 1918 pandemic virus has not been resolved, but its coding sequences are very like those of avian influenza virus. The proteins encoded by the 1918 virus differ from typical low-pathogenicity avian influenza viruses at only a small number of amino acids in each open reading frame. In this study, a series of chimeric 1918 influenza viruses were created in which each of the eight 1918 pandemic virus gene segments was replaced individually with the corresponding gene segment of a prototypical low-pathogenicity avian influenza (LPAI) H1N1 virus in order to investigate functional compatibility of the 1918 virus genome with gene segments from an LPAI virus and to identify gene segments and mutations important for mammalian adaptation. This set of eight "7:1" chimeric viruses was compared to the parental 1918 and LPAI H1N1 viruses in intranasally infected mice. Seven of the 1918 LPAI 7:1 chimeric viruses replicated and caused disease equivalent to the fully reconstructed 1918 virus. Only the chimeric 1918 virus containing the avian influenza PB2 gene segment was attenuated in mice. This attenuation could be corrected by the single E627K amino acid change, further confirming the importance of this change in mammalian adaptation and mouse pathogenicity. While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus.</AbstractText>
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</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
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<History>
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<Month>6</Month>
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<ArticleId IdType="pubmed">22718825</ArticleId>
<ArticleId IdType="pii">JVI.00887-12</ArticleId>
<ArticleId IdType="doi">10.1128/JVI.00887-12</ArticleId>
<ArticleId IdType="pmc">PMC3416129</ArticleId>
</ArticleIdList>
<ReferenceList>
<Reference>
<Citation>J Virol. 2008 Jan;82(2):596-601</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17942553</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Microbiol Rev. 1992 Mar;56(1):152-79</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">1579108</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3064-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18287069</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virology. 2011 Apr 10;412(2):426-34</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21334038</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2010;5(2):e9025</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20140252</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Influenza Other Respir Viruses. 2011 May;5(3):198-205</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21477139</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Bull Hist Med. 2002 Spring;76(1):105-15</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11875246</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Arch Virol. 2000;145(1):187-95</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10664417</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2008 May;4(5):e1000076</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18516303</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2005 Oct 7;310(5745):77-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16210530</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2007 Jan 18;445(7125):319-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17230189</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Host Microbe. 2008 Aug 14;4(2):111-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18692771</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2008 Feb 8;4(2):e11</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18248089</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Microbiol Mol Biol Rev. 2008 Sep;72(3):457-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18772285</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6785-90</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10823895</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 1993 Apr;67(4):1761-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">8445709</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 1977 Dec 15;270(5638):617-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">593388</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Rev Microbiol. 2004 Nov;2(11):909-14</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15494747</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2006 Dec;80(23):11887-91</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16987977</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virology. 2011 Feb 5;410(1):1-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21074235</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1871-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11779386</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2009 Apr;83(7):2851-61</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19144714</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Rev Sci Tech. 2009 Apr;28(1):187-202</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19618626</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2012 Feb;86(3):1750-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22090127</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2007 Oct 5;3(10):1374-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17922570</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Gen Virol. 2000 May;81(Pt 5):1283-91</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10769071</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2009 Jun;83(11):5485-94</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19297491</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2004 Oct 7;431(7009):703-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15470432</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>MBio. 2010 May 18;1(1):null</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20689744</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2006 Oct 5;443(7111):578-81</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17006449</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):588-92</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19114663</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2002 Nov;76(21):10717-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12368314</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Clin Microbiol. 1992 Mar;30(3):655-62</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">1551982</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2006 Sep 15;313(5793):1573; author reply 1573</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16973862</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Antivir Ther. 2007;12(4 Pt B):581-91</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17944266</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2010;6(8):e1001034</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20700447</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2009 Jul 10;325(5937):197-201</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19465683</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>MBio. 2011;2(4). pii: e00151-11. doi: 10.1128/mBio.00151-11</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21846828</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709-12</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19597152</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2011 Oct;85(20):10691-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21849466</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Rev Sci Tech. 2009 Apr;28(1):161-73</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19618624</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2004 Nov;78(22):12462-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15507633</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2007 Oct 5;3(10):1414-21</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17922571</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>N Engl J Med. 2009 Jul 16;361(3):225-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19564629</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2004 Sep;78(17):9499-511</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15308742</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2010 Apr;84(8):3752-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20130063</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2007 Feb 2;315(5812):655-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17272724</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Gen Virol. 2006 Dec;87(Pt 12):3655-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17098982</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3166-71</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">14963236</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2006 Apr 27;440(7088):E8; discussion E9-10</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16641948</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2009 Jun 25;459(7250):1122-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19516283</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Gen Virol. 2011 Jul;92(Pt 7):1650-61</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21471313</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10736-41</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12149435</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2007 Oct;81(19):10292-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17652405</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2001 Sep 7;293(5536):1840-2</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11546875</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18590-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16339318</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Rev Sci Tech. 2000 Apr;19(1):197-225</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11189716</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Annu Rev Microbiol. 2008;62:403-24</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18785841</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1356-61</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">14745020</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Host Microbe. 2010 Jun 25;7(6):440-51</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20542248</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Struct Mol Biol. 2007 Mar;14(3):229-33</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17310249</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1651-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">9990079</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2009 Apr;83(8):3754-61</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19211766</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2006 Apr 27;440(7088):E9; discussion E9-10</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16641950</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2005 Oct 6;437(7060):889-93</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16208372</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Emerg Infect Dis. 2006 Jan;12(1):15-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16494711</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21312-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19995968</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virology. 2009 Oct 25;393(2):338-45</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19733889</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2009 May;83(9):4287-96</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19224986</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<country>
<li>États-Unis</li>
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<region>
<li>Maryland</li>
</region>
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